Is Tylenol 3 with codeine is that a pain pill?

This combination medication is used to help relieve mild to moderate pain. It contains an opioid pain reliever (codeine) and a non-opioid pain reliever (acetaminophen) .

What's the difference between Tylenol #3 and Tylenol 4?

3 Tylenol #3 has 30 mg. of codeine; #4 has 60 mg. of codeine .

How much does Tylenol #3 cost?

The cost for Tylenol with Codeine #3 oral tablet (300 mg-30 mg) is around $10 for a supply of 15 tablets , depending on the pharmacy you visit.

Is Tylenol 3 with codeine stronger than hydrocodone?

These are both prescription medications, so your doctor will decide which one would be best for you based on your symptoms and the cause of your pain. Codeine is typically used for mild to moderately severe pain. Hydrocodone is stronger, so it's used for moderate to moderately severe pain .

Is Tylenol 3 with codeine stronger than tramadol?

There are more similarities between codeine and tramadol than differences. First and foremost, both are opioids and narcotics. They can both be used to treat moderate pain, and codeine is about twice as potent . One of the primary differences is that codeine is derived from the poppy plant, just like morphine.

Is Tylenol 3 with codeine better than ibuprofen?

Drugs were distinguishable from placebo in total analgesic effect and ibuprofen was more effective than acetaminophen plus codeine , especially in terms of duration. While peak effects were comparable, they occurred 1 h later following ibuprofen.

Is codeine an opiate?

Codeine is an opioid drug closely related to morphine and, like morphine, is derived from opium poppies. Codeine can cause opioid tolerance, dependence, addiction, poisoning and in high doses, death.

Is Tylenol 4 a narcotic?

Frequently asked questions about Tylenol with Codeine Yes, Tylenol with Codeine (acetaminophen / codeine) is considered a narcotic because it contains codeine, an opioid pain medication.

Is Tylenol 3 any good?

It is typically only used if other pain medications haven't worked. Tylenol #3 isn't for everyone. It can be addictive and may cause withdrawal symptoms . It may also cause serious side effects like respiratory depression and liver damage.

Do you need a prescription for Tylenol 3?

About opioids Doctors, nurse practitioners and dentists prescribe opioids to treat moderate to severe pain. If your health care provider prescribes you pain medication, take the medication exactly as prescribed . Opioids that are often prescribed are: codeine (for example, Tylenol #3)

Is Tylenol 3 still on the market?

The brand-name products — know as Tylenol with Codeine #1, #2, #3, or #4 — are no longer available , but there are still generic versions on the market. Pain relief with Tylenol with Codeine can be just that: a big relief.

Is codeine a pain killer?

Codeine is a painkiller that is part of a group of medicines called opiates. It's used to treat pain, for example, after an operation or an injury. It's also used for ongoing pain when painkillers such as paracetamol, ibuprofen and aspirin have not worked. Codeine is also used to treat diarrhoea.

What does Tylenol with codeine look like?

Acetaminophen and Codeine Phosphate Tablets, USP 300 mg /30 mg are white, round, flat, beveled edged tablets debossed “IP 33” on obverse and “3” on reverse . Store Acetaminophen and Codeine Phosphate Tablets, USP 300 mg/30 mg at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].

Tylenol with Codeine, Tylenol #3 (codeine/acetaminophen) dosing, indications, interactions, adverse effects, and more (2024)

acrivastine

acrivastine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

amisulpride

amisulpride and codeine both increase sedation. Avoid or Use Alternate Drug.

asenapine

asenapine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

asenapine transdermal

asenapine transdermal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

avapritinib

avapritinib and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

benzhydrocodone/acetaminophen

benzhydrocodone/acetaminophen, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzhydrocodone/acetaminophen and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

bremelanotide

bremelanotide will decrease the level or effect of codeine by Other (see comment). Avoid or Use Alternate Drug. Bremelanotide may slow gastric emptying and potentially reduces the rate and extent of absorption of concomitantly administered oral medications. Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. Interactions listed are representative examples and do not include all possible clinical examples.

brimonidine

brimonidine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

buprenorphine

buprenorphine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

buprenorphine buccal

buprenorphine buccal, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

buprenorphine subdermal implant

buprenorphine subdermal implant and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

buprenorphine transdermal

buprenorphine transdermal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

buprenorphine, long-acting injection

buprenorphine, long-acting injection and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

butorphanol

butorphanol, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

calcium/magnesium/potassium/sodium oxybates

codeine, calcium/magnesium/potassium/sodium oxybates.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

cariprazine

cariprazine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

clonidine

clonidine, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.

dacomitinib

dacomitinib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities.

desloratadine

desloratadine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

diazepam buccal

diazepam buccal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatediazepam buccal, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

diazepam intranasal

diazepam intranasal, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.diazepam intranasal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

eluxadoline

codeine, eluxadoline.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions. .

fentanyl

fentanyl, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

fentanyl intranasal

fentanyl intranasal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

fentanyl iontophoretic transdermal system

fentanyl iontophoretic transdermal system and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

fentanyl transdermal

fentanyl transdermal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

fentanyl transmucosal

fentanyl transmucosal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

givosiran

givosiran will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.

hydrocodone

hydrocodone, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

isocarboxazid

isocarboxazid increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

levetiracetam

levetiracetam and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

levocetirizine

levocetirizine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

linezolid

linezolid increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

loratadine

loratadine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

methohexital

methohexital and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

methylene blue

methylene blue and codeine both increase serotonin levels. Avoid or Use Alternate Drug. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicities

metoclopramide intranasal

codeine, metoclopramide intranasal.Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

nalbuphine

nalbuphine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

olopatadine intranasal

codeine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.

ozanimod

ozanimod and codeine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.

pentazocine

pentazocine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

phenelzine

phenelzine increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

prasugrel

codeine will decrease the level or effect of prasugrel by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Co-administration of opioid agonists delay and reduce absorption of prasugrel and its active metabolite presumably by slowing gastric emptying; consider the use of a parenteral anti-platelet agent in acute coronary syndrome patients requiring co-administration of opioid agonists

procarbazine

procarbazine increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. MAOIs may potentiate CNS depression and hypotension. Do not use within 14 days of MAOI use. .

rasagiline

rasagiline increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.

selegiline transdermal

selegiline transdermal increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.

selinexor

selinexor, codeine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.

sodium oxybate

codeine, sodium oxybate.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

sufentanil SL

sufentanil SL, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

ticagrelor

codeine will decrease the level or effect of ticagrelor by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Co-administration of opioid agonists delay and reduce absorption of ticagrelor and its active metabolite presumably by slowing gastric emptying; consider the use of a parenteral anti-platelet agent in acute coronary syndrome patients requiring co-administration of opioid agonists

tramadol

tramadol, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tramadol may reinitiate opiate dependence in pts. previously addicted to other opiates; it may also provoke withdrawal Sx. in pts. who are currently opiate dependent.

tranylcypromine

tranylcypromine increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

valerian

valerian and codeine both increase sedation. Avoid or Use Alternate Drug.

zuranolone

codeine, zuranolone.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of zuranolone with other CNS depressants may increase impairment of psychom*otor performance or CNS depressant effects. If unavoidable, consider dose reduction. .

abiraterone

abiraterone increases levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.

albuterol

codeine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

alfentanil

alfentanil and codeine both increase sedation. Use Caution/Monitor.

alprazolam

alprazolam and codeine both increase sedation. Use Caution/Monitor.

amiodarone

amiodarone will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

amitriptyline

codeine and amitriptyline both increase sedation. Use Caution/Monitor.

amobarbital

amobarbital and codeine both increase sedation. Use Caution/Monitor.

amoxapine

codeine and amoxapine both increase sedation. Use Caution/Monitor.

amphetamine

codeine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

apomorphine

codeine and apomorphine both increase sedation. Use Caution/Monitor.

arformoterol

codeine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

aripiprazole

codeine and aripiprazole both increase sedation. Use Caution/Monitor.

armodafinil

codeine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

artemether/lumefantrine

artemether/lumefantrine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

azelastine

azelastine and codeine both increase sedation. Use Caution/Monitor.

baclofen

baclofen and codeine both increase sedation. Use Caution/Monitor.

belladonna and opium

codeine and belladonna and opium both increase sedation. Use Caution/Monitor.

benperidol

codeine and benperidol both increase sedation. Use Caution/Monitor.

benzphetamine

codeine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

brexanolone

brexanolone, codeine.Either increases toxicity of the other by sedation. Use Caution/Monitor.

brexpiprazole

brexpiprazole and codeine both increase sedation. Use Caution/Monitor.

brivaracetam

brivaracetam and codeine both increase sedation. Use Caution/Monitor.

brompheniramine

brompheniramine and codeine both increase sedation. Use Caution/Monitor.

buprenorphine

buprenorphine and codeine both increase sedation. Use Caution/Monitor.

buprenorphine buccal

buprenorphine buccal and codeine both increase sedation. Use Caution/Monitor.

buprenorphine, long-acting injection

codeine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.

bupropion

bupropion will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents the conversion of codeine to its active metabolite morphine.

butabarbital

butabarbital and codeine both increase sedation. Use Caution/Monitor.

butalbital

butalbital and codeine both increase sedation. Use Caution/Monitor.

butorphanol

butorphanol and codeine both increase sedation. Use Caution/Monitor.

caffeine

codeine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

carbinoxamine

carbinoxamine and codeine both increase sedation. Use Caution/Monitor.

carisoprodol

carisoprodol and codeine both increase sedation. Use Caution/Monitor.

celecoxib

celecoxib decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

cenobamate

cenobamate, codeine.Either increases effects of the other by sedation. Use Caution/Monitor.

chloral hydrate

chloral hydrate and codeine both increase sedation. Use Caution/Monitor.

chlordiazepoxide

chlordiazepoxide and codeine both increase sedation. Use Caution/Monitor.

chloroquine

chloroquine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

chlorpheniramine

chlorpheniramine and codeine both increase sedation. Use Caution/Monitor.

chlorpromazine

codeine and chlorpromazine both increase sedation. Use Caution/Monitor.chlorpromazine will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine

chlorzoxazone

chlorzoxazone and codeine both increase sedation. Use Caution/Monitor.

cimetidine

cimetidine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

cinacalcet

cinacalcet decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

cinnarizine

cinnarizine and codeine both increase sedation. Use Caution/Monitor.

clemastine

clemastine and codeine both increase sedation. Use Caution/Monitor.

clobazam

codeine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clobazam decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

clomipramine

codeine and clomipramine both increase sedation. Use Caution/Monitor.clomipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

clonazepam

clonazepam and codeine both increase sedation. Use Caution/Monitor.

clorazepate

clorazepate and codeine both increase sedation. Use Caution/Monitor.

clozapine

codeine and clozapine both increase sedation. Use Caution/Monitor.clozapine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

cocaine topical

cocaine topical decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

cyclizine

cyclizine and codeine both increase sedation. Use Caution/Monitor.

cyclobenzaprine

cyclobenzaprine and codeine both increase sedation. Use Caution/Monitor.

cyproheptadine

cyproheptadine and codeine both increase sedation. Use Caution/Monitor.

dantrolene

dantrolene and codeine both increase sedation. Use Caution/Monitor.

daridorexant

codeine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.

darifenacin

darifenacin decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

desflurane

desflurane and codeine both increase sedation. Use Caution/Monitor. Opioids may decrease MAC requirements, less inhalation anesthetic may be required.

desipramine

codeine and desipramine both increase sedation. Use Caution/Monitor.desipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

desvenlafaxine

desvenlafaxine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg

deutetrabenazine

codeine and deutetrabenazine both increase sedation. Use Caution/Monitor.

dexchlorpheniramine

dexchlorpheniramine and codeine both increase sedation. Use Caution/Monitor.

dexfenfluramine

codeine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dexmedetomidine

dexmedetomidine and codeine both increase sedation. Use Caution/Monitor.

dexmethylphenidate

codeine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dextroamphetamine

codeine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dextromoramide

codeine and dextromoramide both increase sedation. Use Caution/Monitor.

diamorphine

codeine and diamorphine both increase sedation. Use Caution/Monitor.

diazepam

diazepam and codeine both increase sedation. Use Caution/Monitor.

diethylpropion

codeine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

difelikefalin

difelikefalin and codeine both increase sedation. Use Caution/Monitor.

difenoxin hcl

codeine and difenoxin hcl both increase sedation. Use Caution/Monitor.

dimenhydrinate

dimenhydrinate and codeine both increase sedation. Use Caution/Monitor.

diphenhydramine

diphenhydramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.diphenhydramine and codeine both increase sedation. Use Caution/Monitor.

diphenoxylate hcl

codeine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

dipipanone

codeine and dipipanone both increase sedation. Use Caution/Monitor.

dobutamine

codeine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dopamine

codeine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dopexamine

codeine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

dosulepin

codeine and dosulepin both increase sedation. Use Caution/Monitor.

doxepin

codeine and doxepin both increase sedation. Use Caution/Monitor.

doxylamine

doxylamine and codeine both increase sedation. Use Caution/Monitor.

dronedarone

dronedarone decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

droperidol

codeine and droperidol both increase sedation. Use Caution/Monitor.

duloxetine

duloxetine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

elvitegravir/cobicistat/emtricitabine/tenofovir DF

elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.

ephedrine

codeine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Tylenol with Codeine, Tylenol #3 (codeine/acetaminophen) dosing, indications, interactions, adverse effects, and more (2024)

FAQs

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